Desmopressin is a synthetic analogue of the natural hormone neurohypophysis (posterior lobe of the pituitary gland), vasopressin (antidiuretic hormone). Compared with the natural hormone is significantly higher antidiuretic effect (reduced urine output), but almost no effect on smooth muscles. Melt MINIRIN product is indicated for: for the treatment of central diabetes insipidu; for the treatment of primary nocturnal enuresis (enuresis nocturna) in patients (from five years of age) with normal ability to concentrate urine; for the symptomatic treatment of adult cases of nocturia associated with nocturnal polyuria, ie nocturnal urine production exceeding bladder capacity. Take special care with
MINIRIN Melt is needed When used in medicine for the treatment of primary nocturnal enuresis and nocturia indication must be fluid intake in the period between 1 hour before administration, and 8 hours after administration limited. The total fluid intake during this period should not exceed 2 ounce glass.
Treatment without concomitant reduction of fluid intake may lead to retention (retention) of water and / or hyponatremia (low sodium levels in the blood plasma) with warning signs and symptoms (headache, nausea / vomiting, weight gain, and in severe cases, convulsions) or without . In conditions when the patient has an increased need for fluids (such as systemic infections, fever, acute inflammation of the stomach) discontinue treatment and consult your doctor.
It is also necessary to pay special attention to the treatment of Minirinem in the following cases: patients treated with diuretic medications for concomitant treatment with drugs that can stimulate secretion of antidiuretic hormone from the neurohypophysis - tricyclic antidepressants, selective serotonin reuptake inhibitors, chlorpropamide, carbamazepine, clofibrate and concurrent treatment with non-steroidal anti-inflammatory drugs. Melt MINIRIN product can be used in pregnancy and lactation, the physician must always consider the benefits against the risks. Taking other medicines And the effects of other drugs may interact.
The doctor should be informed about all the medicines you are taking, or start to take, on prescription or without it. Non-steroidal anti-inflammatory drugs (group of drugs used in diseases of the musculoskeletal system and rheumatism) can induce retention (retention) in the body fluids and hyponatremia (low sodium levels in the blood plasma). Effects of diuretics (water substances used mainly to treat high blood pressure, coronary heart disease and kidney disease) and desmopressin attenuate each other.
Drugs that promote secretion of antidiuretic hormone from the neurohypophysis eg tricyclic antidepressants, selective serotonin reuptake inhibitors, carbamazepine, chlorpropamide and clofibrate, may lead to an additive effect of ADH, which leads to an increased risk retention (retention) of water, or hyponatremia (low sodium levels in the blood plasma). Concomitant treatment with loperamide (the active ingredient of some drugs against diarrhea) may lead to an increase in the plasma concentration of desmopressin, which may result in increased risk of urinary retention (retention) of water and hyponatremia (low sodium levels in the blood plasma). Although not proven research, may cause the same effects as other drugs that slow intestinal peristalsis.